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Visit and research presentation of Prof. Xiaoyang Xu from New Jersey Institute of Technology

On the morning of December 26th 2016,Prof. Xiaoyang Xu from New Jersey Institute of Technology visited our university at the invitation of Prof. Runhui Liu, and gave a wonderful talk entitled Engineering Nanoparticles for Diagnostics and Therapeutics.

 

The report mainly  focus on the development of new applications in controlled assembly, biodiagnostics, bio-imaging, anticancer drug delivery and targeted therapies based upon novel nanoparticle constructs. Professor Xiaoyang Xu discussed the challenges of nanomedicine first, and then described biodiagnostic applications of DNA-AuNPs for the detection of enzyme inhibitors, cancer biomarkers and MRI contrast agents. He also introduced a new method for asymmetrically functionalizing gold nanoparticles (AuNPs) with oligonucleotides and programming their assembly into complex higher order architectures. Secondly, Professor Xu talk about PLGA-PEG based polymeric nanoparticles as drug delivery carriers for the treatment of cancer, cardiovascular disease and obesity. In particular, a siRNA and anticancer drug co-delivery approach has been developed for the treatment of multiple drug resistance (MDR) tumor. Similarly, targeted therapy of atherosclerosis can significantly reduce the side effects of convertional drugs on the human liver. The use of nanoparticles in the field of obesity is also the latest targeted approach that stimulates angiogenesis in adipose tissue with no side effects, and promotes the transformation of stored fat white tissue into brown fat-burning tissue. Finally, faculties and students asked multiple questions that were all answered by Professor Xu in detail.

 

 

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Dr. Xiaoyang Xu is an assistant professor in the Department of Chemical, Biological and Pharmaceutical Engineering at New Jersey Institute of Technology. He received his B.E. in Chemical Engineering from East China University of Science and Technology in China. He completed his Ph.D. in Material Chemistry at Northwestern University under the supervision of Prof. Chad Mirkin. He received a joint NIH postdoctoral fellow in the laboratories of Professors Robert Langer at MIT and Omid Farokhzad at Harvard Medical School. His research focus is cross-disciplinary fields of biomaterials and medicine including drug delivery and regenerative medicine. He looks at both fundamental and applied questions in order to develop novel therapeutic methods for the treatment of cancer, obesity, and cardiovascular disease. Professor Xu has received numerous awards including the Ruth L. Kirschstein National Research Service Award, the AACR Scholar-in-Training Award and 1000 Plan Professorship for Young Talent. His research has been published in high-impact journals such asPNAS, JACS, ANGEW, ACS Nano, Nano Letters, Small and Advanced Materials.