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Advanced Functional Materials: Biofabricated Coating for Tumor Targeting and Drug Delivery

Recently, Jinyang Li, a master student in School of Materials Science and Engineering, haspublished a first-authored paper titled “Biospecific self-assembly of a nano-particle coating for targeted and stimuli-responsive drug delivery” on Advanced Functional Materials. This work is supervised by Prof.Changsheng Liu and Dr. Xue Qu. 

 

Advances in the biological and life sciences suggest exciting opportunities to biomaterials. Using natural macromolecules and their physiological mechanisms, materials scientist can build smart biomaterials that meet exacting requirements. Inspired by the pH-dependent biospecific recognition between lectinCon A (Concanavalin A) and saccharides such asmannose, glucose, and glycoconjugates containing mannose or glucose moiety, Prof. Liu and his team reported a biologically based nanoparticle coating system based on sugar-lectinbiorecognition between polysaccharides glycogen, glycoprotein transferrin and lectin Con A. As illustrated in the Scheme, this coating system built upon mesoporous silica nanoparticles is capable of targeting cancer cell lines through a transferrin receptor-mediated endocytosis mechanism and dis-assembly at the low pHs that characterize endosomes, which provides a mechanism for the triggered release of a nanoparticle cargo. In vitro study showed that the Con A-glycogen-transferrin coating system enhancedcytotoxicities for cancer cell lines but attenuatedcytotoxicities for noncancerous cell lines.  

 

Scheme. The self-assembly of biomaromolecules and mechanism of targeted drug delivery

 

 Scheme. The self-assembly of biomaromolecules and mechanism of targeted drug delivery

 

Importantly, this work illustrates the potential for enlisting biology as a source of materials and mechanisms to perform advanced materials functions to meet the emerging demands for applications in the medical and life sciences. Wiley China has reported this work:http://www.materialsviewschina.com/2015/02/use-of-natural-macromolecules-and-their-physiological-mechanism-to-build-smart-biomaterials/. More details of this work can be found in: http://onlinelibrary.wiley.com/doi/10.1002/adfm.201403636/abstract.